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A new season at the Sant’Angelo Hospital finds Anna and Giacomo finally together. As for Angelo, he has been put in charge of the Emergency Room, while Bergamini is under fire from the hospital administrators and Marco is about to get married. A promotion puts Olga back in the thick of things. Gabriella suffers a setback, though the event ultimately reinvigorates her. New characters include Letizia, a beautiful, seemingly unflappable doctor whose fragility is revealed further on, and Matteo, an aspiring specialist whose dream, until it was shattered, was to become a racing driver.

The most famous Italian crime series in DVD